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Laitetaan perään myös Rhondan mietteitä carnivoresta.
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The Joe Rogan Experience #1178 - Dr. Rhonda Patrick - Podcast NotesThe Carnivore Diet
More of Rhonda’s Concerns with the Carnivore Diet
- “The diet could be dangerous without any long term evidence or scientific studies’
- The diet does seem to improve autoimmune disorders
- Why does it work?
- Calorie restriction and fasting have been shown to allow for significant improvements in autoimmune diseases
- People eat less when they eat a high protein diet
- You have less insulin production, which changes your leptin and ghrelin levels (the satiety and hunger hormones, respectively), which causes you to eat less
- Studies show that when people are given the same food every single day, naturally they start to eat less, and calorie restrict themselves
- It replenishes the immune system through apoptosis
- While fasting, or just calorie restricting to very low levels, entire cells are cleared away through a process known as apoptosis
- During a 72 hour fast, animal studies show you can clear away about 30% of the immune system and replenish it with brand new healthy immune cells
- Organs shrink during the fasting, and then re-expand when you eat
- Autoimmune cells may be selectively killed off first, and replenished with non-autoimmune cells
- It produces changes in the microbiome
- The microbiome has been linked to autoimmunity in things like arthritis and multiple sclerosis (MS)
- One study showed that when people with MS fasted every other day for 7 days, they experienced profound changes in the gut microbiome
- They grew gut bacteria which produce more butyrate (this is a short chain fatty acid which gut cells love – it’s good for them), which helps the immune system produce for T-regulatory cells
- There are negative changes, in terms of the gut microbiome that occur when following a carnivore diet
- People that go from a high fiber, to a high protein (or carnviore diet), will tend create an environment in the gut that allows for the presence of more bacteria that ferment amino acids (like putrefactive bacteria)
- Why is this not desirable? – Some species of putrefactive bacteria have been linked to colon cancer
- These bacteria create genotoxic agents known as putracine and cadaverine which damage the DNA inside colon cells
- By eating fiber/vegetables along with meat/protein – this promotes the growth of lactic acid producing bacteria (bifiodo, lactobacilius etc.) , which limits limits the growth of putrefactive bacteria
- There are other ways to cure or help autoimmune issues, without going on such a restrictive diet
- Do a prolonged fast 1x a quarter, depending on how severe the issues are
- Do a fasting mimicking diet (FMD) once per month
- For more on a FMD, check out these Podcast Notes
- One study showed that going on a ketogenic diet for three months, also improved symptoms of autoimmunity
- “At the end of the day, there’s no data” – Going on a carnivore diet may be harmful long term
- Rhonda has concerns about micronutrients (check out these Podcast Notes where Rhonda talks more about micronutrients)
- Micronutrients (30 particular vitamins and minerals) are essential
- They run our metabolism, are involved in making neurotransmitters, etc.
- 22% of all enzymes in your body require a micronutrient to function
- You don’t make micronutrients in your body, so you have to get them from your diet
- How are RDAs of micronutrients set?
- First, the EAR (estimated average intake) is looked at – you look at a given population, and determine how much of a given micronutrient the population needs so that 50% of the population has adequate levels
- The RDA is set from that, 2 standard deviations above
- For each micronutrient it’s different
- “RDAs are set to prevent acute disease, but what about promoting optimal health”
- Many micronutrients are much more concentrated, and easy to get, from plants
- The biggest one of concern is vitamin C
- Vitamin C is important for making collagen, converting dopamine to norepinepherine (important for the fight or flight response), and is an antioxidant
- Scurvy happens when you don’t have enough vitamin C for collagen production (this is thought to be about only 10mg/day – it doesn’t take much)
- So people on a carnivore diet are probably getting enough Vitamin C to prevent scurvy. but perhaps not enough to cover all the other things vitamin C is required for
- Vitamin C has two forms – ascorbic acid (the reduced form – aka the antioxidant) and an oxidized form (dehydroascorbic acid)
- The RDA for vitamin C is 90 mg/day for men and 75 mg/day for women
- It’s been shown in guinea pigs, there are biological differences (even 10 fold) into how much vitamin C they required
- Vitamin E is also a concern
- Vitamin E helps recycle vitamin C and vice versa
- It’s an antioxidant, but is also important for maintaining cell integrity – it’s located inside the cell membrane and prevents normal oxidative processes from happening there
- The RDA is 15 mg
- Nuts are the best source (almonds) of vitamin E, and sardines
- Folate too…
- Folate plays an important role in making new DNA
- So low levels of folate, can lead to DNA damage – this is very hard to measure, and you don’t even know it’s happening
- Magnesium
- Enzymes to repair DNA damage require magnesium
- Beef liver is a great source of magnesium
- If you lack micronutrients…
- There are enzymes that are required to prevent and repair DNA damage, and then there are enzymes that require a micronutrient to prevent short term disease
- If there’s only so much of a micronutrient around, it will be used for the latter
- What if you just ate a bunch of organ meat to get the micronutrients you’d be missing from vegetables?
- You can do it – but it’s difficult, and most people probably won’t do it
- By not eating vegetables, you’re missing out on key fiber that the gut needs
- “We evolved eating plants”
- There’s all these other things present in plants that people following a carnivore diet are missing out on – falvonoids, polyphenols, phytochemicals, etc.
- You’re missing out on SULFORAPHANE
- Broccolli sprouts are the biggest source, but it’s also present in brussel sprouts
- Sulforaphane activates a variety of enzymes which help get rid of potentially harmful compounds in the body
- Humans given sulforaphane extract show an increase of glutathione (a master antioxidant) in the brain – it plays a huge role in preventing brain aging
- Sulforaphane has been found to improve symptoms of autism
- There are literally so many beneficial things that come from eating vegetables – too many to mention
- “Why would you want to eliminate a massive source of bioavailable nutrients” – Joe