Mistä tiedät, että tuo sinun linkittämä tutkimus on totta? Sitten kun linkität kymmenen eri tutkimusta voit sanoa "No tuo nyt vain ei ole totta" niin että se merkitseekin jotain. Voihan tänne jokainen etsiä jostain yhden tutkimuksen, joka todistaa, että kehonrakennus aiheuttaa aivojen kutistumista jopa 50%, mutta onko se sitten totuus?
No tuo aivojen kutistuminen voi hyvinkin olla mahdollista
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Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application
Decio Armaninia, , , Davide Nacamullia, Francesco Francini-Pesentib, Giuliana Battagina, Eugenio Ragazzic and Cristina Fiorea
aDepartment of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy
bDepartment of Clinical and Experimental Medicine-Clinical Nutrition, University of Padua, Italy
cDepartment of Pharmacology, University of Padua, Italy
Received 27 December 2004; revised 21 January 2005; accepted 26 January 2005. Available online 12 April 2005.
Abstract
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11β-hydroxysteroid dehydrogenase.
Glycyrrhetinic acid, the active principle of licorice root, blocks 11β-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes.
We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh.
Eighteen healthy women (age range 20–33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n = 9) or with a placebo cream containing the excipients alone (n = 9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured.
The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream.
No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol.
The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11β-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.
Ja myös B. Stallknechtin ja kumppaneitten tutkimus ('Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans' American Journal of Physiology, 2006 ) viittaa, että 'spot reduction' olisi mahdollista. Tutkimuksessa oli tehty puoli tuntia yhden jalan ojennuksia melko kevyillä painoilla. Treenatussa jalassa lipolyysi oli tehostunut merkittävästi.
