- Liittynyt
- 30.1.2009
- Viestejä
- 328
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We also identified a cluster of obesity-associated changes in specific amino acid, acylcarnitine, and organic acid metabolites in obese compared to lean subjects that was associated with insulin resistance. We hypothesize that these changes may reflect an overload of BCAA catabolism in obese subjects. Subjects that become obese on a typical American diet, as in the current study, consume high levels of fat and protein, and dietary protein is comprised of >20% BCAA (Layman and Walker, 2006 D.K. Layman and D.A. Walker, Potential importance of leucine in treatment of obesity and the metabolic syndrome, J. Nutr. 136 (2006), pp. 319S–323S.Layman and Walker, 2006). We propose that when coupled with overnutrition, the relative IGF-1 deficiency that we document in the obese subjects forces the now-expanded circulating BCAA pool to be diverted away from protein synthesis and into catabolic pathways.
Hmm, tarkoittaako tämä sitten sitä, että jos kerran leusiini stimuloi mTOR -viestiproteiinia kasvun merkeissä, ei insuliinitasojen nostaminen hiilareilla edes carb cycling -hengessä ole tarpeen?
Joo, sitä mä tässä vähän ajoin takaa, mutta kun en ole ihan solubiologi saati biokemisti niin piti kysyä.Meinaatko siis että tuo insutasojen nostaminen ja siitä seuraava mTOR-aktivaatio olisi hiilarisyklittelyn ainoa hyöty?