nosto..
Luimpa tuossa pakkis kaupalla tuota pumped lehteä, jossa tuli taas nuo saatanan järeät rotat vastaan...:D eli juttua oli myostatiini geenistä, joka rajoittaa lihaskasvua. Flex Wheeler:illä on todettu myostatiini geenin mutaatio(jossain oli tutkimus tehtynä).
"SUMMARY: Multiple approaches to inhibiting myostatin are suggested by the recent elucidation of its signaling pathway. An inhibitor of myostatin may be the first drug specifically designed to enhance muscle growth and regeneration."
Lähde:
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=16224249&query_hl=1
"Here we reported that individual major muscles of transgenic mice were 45-115% heavier than those of wild-type mice, maintained normal blood glucose, insulin sensitivity, and fat mass after a 2-month regimen with a high-fat diet (45% kcal fat). In contrast, high-fat diet induced wild-type mice with 170-214% more fat mass than transgenic mice and developed impaired glucose tolerance and insulin resistance. Insulin signaling, measured by Akt phosphorylation, was significantly elevated by 144% in transgenic mice over wild-type mice fed a high-fat diet. Interestingly, high-fat diet significantly increased adiponectin secretion while blood insulin, resistin, and leptin levels remained normal in the transgenic mice. The results suggest that disruption of myostatin function by its propeptide favours dietary fat utilization for muscle growth and maintenance. An increased secretion of adiponectin may promote energy partition toward skeletal muscles, suggesting that a beneficial interaction between muscle and adipose tissue play a role in preventing obesity and insulin resistance."
Lähde:
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=16182246&query_hl=1
"Thus, potential antagonists to myostatin, whether targeting myostatin synthesis, secretion or receptor binding, show great promise as therapies against muscle-wasting diseases. This review provides an expert opinion on the biology and potential of myostatin antagonists in the treatment of muscle-wasting disorders."
Lähde:
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=16144494&query_hl=1
"This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows."
Lähde:
http://www.ncbi.nlm.nih.gov/entrez/...d&dopt=Abstract&list_uids=15851664&query_hl=1
Flex Wheeler:
"BALCO Laboratories has been testing and monitoring Flex on a routine basis during the last year. We have performed tests including blood chemistry (SMAC), complete blood count (CBC), PSA, anabolic hormone levels, genotyping as well as comprehensive testing for nutritional elements. Flex's test results have been compared to twenty-four other professional bodybuilders and overall he has one of the healthiest profiles. Basically, Flex is in excellent health and has demonstrated the discipline necessary to maintain a peak level of conditioning.
Flex was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this landmark study have already been submitted for publication. Flex was also found to have a very unusual type of the IGF-1 gene. In fact, Flex was the only participant in the study that did not have a "match." All of the other extreme responders had at least three other subjects with a matching IGF-1 gene. Based upon Flex's very unique genetic profile, we plan to expeditiously publish a scientific paper that reveals his complete genotype in specific detail. The publication of his remarkable genetic data should generate an enormous amount of media exposure.
Hope this information will be helpful and please call if I can be of assistance.
Sincerely,
/s/ Victor Conte
Victor Conte
President
BALCO Laboratories, Inc."
Lähde:
http://www.musclephotos.com/myogene.html
Laitoin tuon lehtipiste-linkin tuonne loppuun kun kolme tyyppia ehti jo pelkästään tämän viikonlopun aikana kysyä, että mistä noita lehti saa (niitä kun ei tuppaa olemaan ihan jokaisessa kioskissa).
