- Liittynyt
- 17.8.2006
- Viestejä
- 16 422
Summary and directions for futureresearch
The hypothesis that creatine supplementation can mitigatecognitive decline in older adults is biologically plausiblebut unproven.
The central barrier is not only physiological—the limited ability of supplemented creatine tocross the BBB—
but also methodological, with current studies hampered by small sample sizes, heterogeneous designs,and measurement challenges.Future research should:
1. Utilize advanced neuroimaging techniques to quantify brain creatine uptake with greater accuracy.
2. Standardize supplementation protocols, includingdosing strategies tailored for older adults.
3. Investigate interactions with lifestyle interventionssuch as exercise and diet.
4. Ensure independent replications with transparentconflict-of-interest disclosures.Until these gaps are addressed, creatine supplementationfor cognition in aging must be regarded as a promisinghypothesis rather than established clinical practice
pubmed.ncbi.nlm.nih.gov
The hypothesis that creatine supplementation can mitigatecognitive decline in older adults is biologically plausiblebut unproven.
The central barrier is not only physiological—the limited ability of supplemented creatine tocross the BBB—
but also methodological, with current studies hampered by small sample sizes, heterogeneous designs,and measurement challenges.Future research should:
1. Utilize advanced neuroimaging techniques to quantify brain creatine uptake with greater accuracy.
2. Standardize supplementation protocols, includingdosing strategies tailored for older adults.
3. Investigate interactions with lifestyle interventionssuch as exercise and diet.
4. Ensure independent replications with transparentconflict-of-interest disclosures.Until these gaps are addressed, creatine supplementationfor cognition in aging must be regarded as a promisinghypothesis rather than established clinical practice
Creatine supplementation and cognitive aging: The challenge of crossing the blood-brain barrier - PubMed
<span><b>Background:</b> Creatine supplementation has been widely studied for muscle health and aging. Recently, its possible effects on brain function and cognition in older adults have drawn attention, though consistent clinical evidence remains limited. <b>Aim:</b> To discuss current...
pubmed.ncbi.nlm.nih.gov