Pii sanoi:
Kuinkahan lisäravinne kreatiinin käyttö korreloi ko. tutkimustuloksen kanssa ??
http://www.verkkoklinikka.fi/leiras/sydanlinkki/34.html
Tiedoksi:
http://www.tohtori.fi/termi.php3?terID=4016&termit=kreatiniini
Löytyisikö joltakulta asiantuntijatietoa !! :arvi:
Google tiesi.
"Under normal circumstances without creatine supplementation, increased levels of blood creatinine indicate a decrease in kidney filtration rate (16), which is indeed a sign of kidney dysfunction. However, some clinicians have viewed blood creatinine values with tunnel vision. Because creatine supplementation increases body creatine stores, it would be expected that more creatinine would be produced within the muscle and then released into the blood stream where it could inflate blood creatinine concentration in the absence of kidney problems. Another source of creatinine is from the conversion in the gut of unstable creatine to creatinine which is then taken up into the bloodstream. Several studies--though not all--have shown increased blood creatinine during periods of creatine supplementation (17-19). Also, individuals with greater lean body mass, like many users of creatine, naturally produce greater creatinine (8). Furthermore, physical activity, which typically has accompanied creatine ingestion, also increases blood creatinine levels (8). For these reasons, it is unlikely that isolated elevated creatinine in creatine users indicates pathological changes in the kidney. Aside from the three previously mentioned cases, seven studies with many participants consuming creatine for periods of 5 days to 5 years have found no negative effects of loading or maintenance dosages (roughly 20 g daily or 5 g daily, respectively) of creatine supplementation on kidney function (14,18,20-25). "
8. Baines AD. Disorders of the kidney and urinary tract. In: Gornall AG, ed. Applied Biochemistry of Clinical Disorders. 2nd ed. Philadelphia, Pa: JB Lippincott; 1986:139-171.
14. Poortmans JR, Francaux M. Renal dysfunction accompanying oral creatine supplements [correspondence]. Lancet. 1998;352:234.
16. Guyton AC, Hall JE. Textbook of Medical Physiology. 9th ed. Philadelphia, Pa: WB Saunders; 1996.
17. Kamber M, Koster M, Kreis R, Walker G, Boesch C, Hoppeler H. Creatine supplementation--part I: performance, clinical chemistry, and muscle volume. Med Sci Sports Exerc. 1999;31:1763-1769.
18. Kuehl K, Koehler S, Dulacki K, Goldberg L, Elliot D, Bennett W, Haddock B. Effects of oral creatine monohydrate supplementation on renal function in adults [abstract]. Med Sci Sports Exerc. 2000;32(suppl):S168. Abstract 747.
19. Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P. Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1997;83:2055-2063.
20. Gotshalk LA, Kraemer WJ. The effects of creatine supplementation on the muscular performance of older men [abstract]. Med Sci Sports Exerc. 2000;32(suppl):S137. Abstract 569.
21. Mayhew DL, Satterly TF III, Ware JS, Mayhew JL. Effect of long-term creatine supplementation on liver and kidney function in college football players [abstract]. Med Sci Sports Exerc. 2000;32(suppl):S135. Abstract 558.
22. Millard-Stafford ML, Snow TK, Rosskopf LB. Limited side effects associated with creatine supplementation [abstract]. Med Sci Sports Exerc. 2000;32(suppl):S133. Abstract 545.
23. Poortmans JR, Auquier H, Renaut V, Durussel A, Saugy M, Brisson GR. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol. 1997;76:566-567.
24. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc. 1999;31:1108-1110.
25. Sugiura K, Takasaki M, Ohta A. Creatine supplementation increases the requirement of nutrients (ntrogen [sic] and minerals) in rats with spontaneous exercise [abstract]. Med Sci Sports Exerc. 2000;32(suppl):S136. Abstract 563.