jhulmi
Lihastohtori
- Liittynyt
- 26.8.2003
- Viestejä
- 1 516
Mielenkiintoinen uusi supplementti, joka näyttää vähentävän katabolisen hormonin kortisolin pitoisuuksia levossa ja myös voimaharjoituksen aikana. Tässä lisää tästä arvostetun William Kraemerin ja Jeff Volekin tutkimusryhmän löydöksestä, lukaiskaa:
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15877297
"Cortitrol, a proprietary herbal anticortisol blend containing magnolia bark extract (Magnolia officialis), L-theanine (from Camillia sinensis), Epimedium extract (Epimedium koreanum), phophatidylserine (soy derived), and β-sitosterol. Limited data exist on the effectiveness of these herbal supplements; however, preliminary studies show promising results. Magnolol, a phenolic constituent of magnolia bark, has been shown to suppress cortical serotonin (5-hydroxytryptamine) release [8], which may be advantageous because serotonin plays a role in stress and anxiety–related disorders [9]. L-theanine, commonly found in tea, may prime blood T cells and provide natural resistance to infection [10] and promote brain α-wave [11] and suppress β-wave activity [12]. Epimedium has been shown to lower cortisol levels in animal models [13]. Monteleone et al [14,15] showed that phosphatidylserine supplementation attenuated the cortisol response to physical stress in healthy men. Finally, subjects supplementing with β-sitosterol before competing in a marathon had a decreased inflammatory response, cortisol/dehydroepiandrosterone (DHEA) ratio, and immune suppression during the postmarathon recovery period [16].
Although cortisol is necessary to respond to physiological stress, chronic elevation of cortisol may have negative effects on a host of target tissues, such as reduced immune cell function, protein wasting in muscle, and suboptimal bone metabolism. However, complete elimination of the overt cortisol response to stress would be physiologically inappropriate for normal human health. Thus, Cortitrol was designed and formulated to reduce the magnitude of the overt stress response and absolute cortisol concentrations.
Intense resistance exercise and training has been shown to cause dramatic increases in cortisol levels [17,18]. Furthermore, athletes show elevated cortisol levels in anticipation of intense physical challenge [19]. Therefore, high-intensity resistance exercise provides an ideal forum to test the purported benefits of Cortitrol. The purpose of this investigation was to determine the efficacy of Cortitrol to influence cortisol responses to an intense physical exercise stress model in human beings known to dramatically increase cortisol concentrations in the blood. We hypothesized that supplementation would result in decreased cortisol concentrations before, during, and after the exercise challenge."
...
"The results of this study imply that long-term supplementation with Cortitrol may have a favorable impact on chronic cortisol levels. Thus, the potential exists for improved muscular adaptation to resistance training, increased bone mineral density, and enhanced immune cell function. However, this study is limited in that it examined only acute responses to Cortitrol supplementation. Future studies will need to further examine some of the positive adaptations that may occur from chronic reduction in cortisol concentrations after Cortitrol supplementation.
In conclusion, we investigated the impact of Cortitrol supplementation on serum cortisol responses to intense physical stress via acute resistance exercise. We found that Cortitrol attenuated mean cortisol concentrations throughout a 95-minute period during a day of rest, and during the pre-resistance exercise and early exercise recovery periods. These results give validity to the formulation of Cortitrol as a nutritional supplement. This investigation also opens the door to many avenues of future research."
http://www.ncbi.nlm.nih.gov/entrez/...ve&db=pubmed&dopt=Abstract&list_uids=15877297
"Cortitrol, a proprietary herbal anticortisol blend containing magnolia bark extract (Magnolia officialis), L-theanine (from Camillia sinensis), Epimedium extract (Epimedium koreanum), phophatidylserine (soy derived), and β-sitosterol. Limited data exist on the effectiveness of these herbal supplements; however, preliminary studies show promising results. Magnolol, a phenolic constituent of magnolia bark, has been shown to suppress cortical serotonin (5-hydroxytryptamine) release [8], which may be advantageous because serotonin plays a role in stress and anxiety–related disorders [9]. L-theanine, commonly found in tea, may prime blood T cells and provide natural resistance to infection [10] and promote brain α-wave [11] and suppress β-wave activity [12]. Epimedium has been shown to lower cortisol levels in animal models [13]. Monteleone et al [14,15] showed that phosphatidylserine supplementation attenuated the cortisol response to physical stress in healthy men. Finally, subjects supplementing with β-sitosterol before competing in a marathon had a decreased inflammatory response, cortisol/dehydroepiandrosterone (DHEA) ratio, and immune suppression during the postmarathon recovery period [16].
Although cortisol is necessary to respond to physiological stress, chronic elevation of cortisol may have negative effects on a host of target tissues, such as reduced immune cell function, protein wasting in muscle, and suboptimal bone metabolism. However, complete elimination of the overt cortisol response to stress would be physiologically inappropriate for normal human health. Thus, Cortitrol was designed and formulated to reduce the magnitude of the overt stress response and absolute cortisol concentrations.
Intense resistance exercise and training has been shown to cause dramatic increases in cortisol levels [17,18]. Furthermore, athletes show elevated cortisol levels in anticipation of intense physical challenge [19]. Therefore, high-intensity resistance exercise provides an ideal forum to test the purported benefits of Cortitrol. The purpose of this investigation was to determine the efficacy of Cortitrol to influence cortisol responses to an intense physical exercise stress model in human beings known to dramatically increase cortisol concentrations in the blood. We hypothesized that supplementation would result in decreased cortisol concentrations before, during, and after the exercise challenge."
...
"The results of this study imply that long-term supplementation with Cortitrol may have a favorable impact on chronic cortisol levels. Thus, the potential exists for improved muscular adaptation to resistance training, increased bone mineral density, and enhanced immune cell function. However, this study is limited in that it examined only acute responses to Cortitrol supplementation. Future studies will need to further examine some of the positive adaptations that may occur from chronic reduction in cortisol concentrations after Cortitrol supplementation.
In conclusion, we investigated the impact of Cortitrol supplementation on serum cortisol responses to intense physical stress via acute resistance exercise. We found that Cortitrol attenuated mean cortisol concentrations throughout a 95-minute period during a day of rest, and during the pre-resistance exercise and early exercise recovery periods. These results give validity to the formulation of Cortitrol as a nutritional supplement. This investigation also opens the door to many avenues of future research."
