Heitä tähän väliin joku vitun tieteellinen fakta.
Nykyään tuntuu että kaikki on mahdollista. ysikybäne paikalle ja urli tiskiin, jes!
Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application
Decio Armaninia, , , Davide Nacamullia, Francesco Francini-Pesentib, Giuliana Battagina, Eugenio Ragazzic and Cristina Fiorea
aDepartment of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy
bDepartment of Clinical and Experimental Medicine-Clinical Nutrition, University of Padua, Italy
cDepartment of Pharmacology, University of Padua, Italy
Received 27 December 2004; revised 21 January 2005; accepted 26 January 2005. Available online 12 April 2005.
Abstract
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11β-hydroxysteroid dehydrogenase.
Glycyrrhetinic acid, the active principle of licorice root, blocks 11β-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes.
We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh.
Eighteen healthy women (age range 20–33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n = 9) or with a placebo cream containing the excipients alone (n = 9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured.
The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream.
No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol.
The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11β-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation
JA
http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Ja myös B. Stallknechtin ja kumppaneitten tutkimus ('Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans' American Journal of Physiology, 2006 ) viittaa, että 'spot reduction' olisi mahdollista. Tutkimuksessa oli tehty puoli tuntia yhden jalan ojennuksia melko kevyillä painoilla. Treenatussa jalassa lipolyysi oli tehostunut merkittävästi.
JA
Topical fat reduction from the waist
* M. K. Caruso,11Louisiana State University Division of Human Ecology, Baton Rouge, LA, USA
* S. Pekarovic,22Harbor-UCLA Medical Center, Torrance, CA, USA
* W. J. Raum33LSU Health Sciences Center and St. Charles General Hospital, New Orleans, LA, USA
* F. Greenway44Pennington Biomedical Research Center, Baton Rouge, LA, USAFrank L. Greenway, MD, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
E-mail:
greenwfl@pbrc.edu
* 1Louisiana State University Division of Human Ecology, Baton Rouge, LA, USA
2Harbor-UCLA Medical Center, Torrance, CA, USA
3LSU Health Sciences Center and St. Charles General Hospital, New Orleans, LA, USA
4Pennington Biomedical Research Center, Baton Rouge, LA, USA
Frank L. Greenway, MD, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
E-mail:
greenwfl@pbrc.eduReceived 04 February 2005; returned for revision 25 October 2005; revised version accepted 21 February 2006
Abstract
Objective: Topical fat reduction from the thigh in women using aminophylline cream has been demonstrated, but the local fat reduction in other body areas or in men by lowering the local lipolytic threshold has not been demonstrated. This study is designed to test the hypothesis that aminophylline cream application to the waist will reduce waist circumference compared with a control.
Research methods and procedures: Fifty men and women who are 21–65 years of age with a BMI greater than 27 kg/m2 and a waist to hip ratio ≥average were randomized in a 1 : 1 ratio to 0.5% aminophylline cream to the waist twice a day or no treatment to the waist. All subjects were instructed to follow a 1200 kcal balanced diet, participate in a walking program and return biweekly to encourage compliance. A theophylline level was drawn monthly, and the waist, BMI and waist to hip ratio were remeasured at 12 weeks.
Results: At week 12, there was a significant reduction in BMI from baseline that was not different between the groups. The reduction in waist circumference was 11 ± 1.0 cm in the aminophylline cream group and 5.0 ± 0.6 cm in the control group (p < 0.001). The reduction in waist circumference was significant for both women and men, but the women lost significantly more waist girth. The waist to hip ratio, a measure of fat distribution, declined. Aminophylline levels were undetectable, and there were no adverse events.
Discussion: Aminophylline cream offers a safe and effective method for cosmetic local fat reduction from the waist.
JA
http://ajpendo.physiology.org/cgi/content/full/292/2/E394
Käyn lenkkeilemässä koiran kanssa kevyttä hölkkää noin 7-9 kertaa viikossa. Jalkaprässi ja Mave ovat hyviä mutta onko muita. 
ihan sama syötkö sian vai viisi hernettä päivässä, tai nimitätkö ruokavaliotasi dieetiksi, ketoosiksi vai sikabulkiksi, läski lähtee jos energiaa saadaan vähemmän kuin kulutetaan.
