Se toxicity can affect individuals as a result of occasional overdose that usually occurs with intake of incorrectly formulated supplements (
72) or due to the excess of Se intake in randomized clinical trials, in which doses of 200 μg/day or more are administered for a substantial period of time (
73). Acute toxicity from excessive Se exposure causes stomach pain, headache, respiratory symptoms, changes in blood pressure, vomiting, and nausea. Chronic oral intake of high amounts of Se results in selenosis, a condition characterized by hair loss, deformation and loss of nails, tooth discoloration, garlic breath, gastrointestinal disturbances, skin rash, numbness, paralysis, and occasional hemiplegia (
74). Other outcomes have been reported such as dermatitis, increased mortality (
73), DM2 (
68) and increased incidence of prostate cancer (
67), which are also observed in Se deficiency.