- Liittynyt
- 6.7.2011
- Viestejä
- 1 351
Kaikki pitää selvästi vääntää rautalangasta. Oli puhetta mrna teknologian historiasta. Lue vaikka noi mun linkkaamat artikkelit (jota et selvästi tehnyt) tai sit pidä toi sun jatkuva vänkäys linja " en lue mitään, tiedän faktat kun näen yhden mikasan twitter linkin".Sitten kysymys: Mikä tuo mainitsemasi "todellisuus piikeistä" on? Kun tuo on sama linkitys mikä täällä jo osaltaan on Mikasan postaamana on ollut.
25v sitten tehty ekat mrna rokote testit rotilla ja hiirillä.
here, in 1993, a team led by Pierre Meulien, working with industrial and academic partners, was the first to show that an mRNA in a liposome could elicit a specific antiviral immune response in mice8. (Another exciting advance had come in 1992, when scientists at the Scripps Research Institute in La Jolla used mRNA to replace a deficient protein in rats, to treat a metabolic disorder9. But it would take almost two decades before independent labs reported similar success.)
By the late 1990s, academic collaborators had launched human trials, and Gilboa’s commercial spin-off, Merix Bioscience (later renamed to Argos Therapeutics and now called CoImmune), soon followed with clinical studies of its own. The approach was looking promising until a few years ago, when a late-stage candidate vaccine failed in a large trial; it has now largely fallen out of fashion.
Hoerr was the first to achieve success. While at the University of Tübingen in Germany, he reported in 2000 that direct injections could elicit an immune response in mice12. He created CureVac (also based in Tübingen) that year. But few scientists or investors seemed interested. At one conference where Hoerr presented early mouse data, he says, “there was a Nobel prizewinner standing up in the first row saying, ‘This is completely shit what you’re telling us here — completely shit’.”